The Effectiveness of intra-articular injections hyaluronic acid and corticosteroids in the treatment of patients with knee osteoarthritis symptoms | [Rehman Journal of Health Sciences • 2022]

Author(s):

1. Syed Muhammad Shabbir Ali Naqvi: Hayatabad Medical Complex, Peshawar, Pakistan

2. Fatima Ihsan: Irfan General Hospital, Peshawar, Pakistan

3. Kumail Ijaz: King Edward Medical University, Pakistan

4. Muhammad Usama: King Edward Medical University, Pakistan

5. Faizan Ur Rehman Barki: Norwest Institute of Health Sciences, Pakistan

6. Amjad Ali: Hayatabad Medical Complex, Peshawar, Pakistan

Abstract:

Introduction: Knee osteoarthritis (OA) is a degenerative condition that is caused by the gradual wear and tear of the cartilage that cushions the bones of the knee. This study will find out the effectiveness of intra-articular hyaluronic acid (IAHA) and intra-articular corticosteroids (IACS) in the management of knee OA. Material & Methods: A randomized control trial was conducted in Hayatabad Medical Complex Peshawar and Pak Military Hospital Rawalpindi from March 2019 to June 2021. Total one eighty-two patients were randomly assessed in the study. Treatment group A received intraarticular hyaluronic acid (IAHA), while treatment group B received intra-articular corticosteroids for three months. This study has used Western Ontario and McMaster Universities Arthritis Index (WOMAC) to evaluate the effectiveness of treatment in both groups of knee OA. Results: The study participants mean age was 56.344 ± 7.25. Out of 182 patients, 2 of the patients reported as “loss to follow up” from IACS Tx group b. Treatment groups include 95 (52.7%) female patient while 85 (47.22%) were male patients. 96 (53.33%) received intraarticular hyaluronic acid (IAHA), while 84 (46.66%) received intra-articular steroids (IACS). The pre- and post-treatment mean difference in WOMAC scores in the hyaluronic acid group was 5.52 ± 4.756, while that in the corticosteroid group was 9.495 ± 1.24 (p value < 0.01). Conclusion: Intra-articular steroids (IACS) and hyaluronic acid (IAHA) alone reduces OA symptoms and pain significantly. Yet intra-articular steroids are more effective than intraarticular hyaluronic acid in reducing symptoms of OA at knee.

Page(s): 90-95

DOI: DOI not available

Published: Journal: Rehman Journal of Health Sciences, Volume: 4, Issue: 2, Year: 2022

Keywords:

Osteoarthritis , Corticosteroids , Hyaluronic acid , Knees , effectiveness

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