The Trends of CRP Levels at Different Waist-to-hip Ratios among Normotensive Overweight and Obese Patients: a Pilot Study. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2016]

Author(s):

1. Samar Firdous: Department of Medicine, King Edward Medical University, Lahore, Pakistan

2. Momar Khan Lodhi: Health Department Punjab, Mayo Hospital, Lahore, Pakistan

3. Kashif Siddique: Health Department Statistician, Mayo Hospital, Lahore, Pakistan

Abstract:

Objective: To determine the correlation between CRP (C-reactive protein) and Waist to Hip Ratio (WHR) among over weight and obese patients with normal blood pressure. Study Design: An analytical study. Place and Duration of Study: Medical indoor and outpatient clinics of Mayo Hospital, Lahore, from March to August 2013. Methodology: Willing patients with Body Mass Index (BMI) of > 23 kg/m2, normal blood pressures, and age between 18 - 65 years were inducted in the study. Patients with signs of fluid retention, collagen vascular disease, CAD, on corticosteroids, immunomodulators or lipid lowering medications, hypertensives and febrile patients were excluded. Patients were considered to be at low risk for cardiovascular events if WHR among males and females was 1 and > 0.85, respectively were taken as high risk. Levels in-between these ranges were taken as moderate risk. Data was analyzed on SPSS 15. Descriptive statistics were determined. The p-value was calculated by ANOVA and independent sample t-test among males and females respectively, to compare WHR in relation to different CRP levels and < 0.05 was taken as significant. Results: There were 34 male and 74 female patients. The gender-wise mean WHR did not show statistically significant difference categorized CRP levels (p=0.072 in male, and 0.052 in females). There was an increasing trend in CRP levels as WHR increased among females, but this was statistically insignificant (p=0.05). Conclusion: Although the impact of central obesity on cardiac health is well known, however, WHR alone is an unreliable indicator of systemic inflammation and raised CRP level.

Page(s): 191-194

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 26, Issue: 3, Year: 2016

Keywords:

Keywords are not available for this article.

References:

[1] StephenRD,JohnAM,DennisLS,PhilipK,ThomasRK, 1999.Association of body fat distribution and cardiovascular risk factors in children and adolescents,Circulation 99 541 -5

[2] AucouturierJ,MeyerM,ThivelD, 2009.Effect of android to gynoid fat ratio on insulin resistance in obese youth,Arch Pediatr Adolesc Med 163 826 -31

[3] Sánchez-GarcíaS,García-PeñaC,Duque-LópezMX,JuárezCedilloT,Cortés-NúñezAR,Reyes-Beaman S, 2007.Anthropometric measures and nutritional status in a healthy elderly population,BMC Public Health 7 2 -

[4] 2011.Waist circumference and waist-hip ratio, report of a WHO expert consultation, -

[5] PanoulasVF,AhmadN,FazalAA,NightingaleP,KitasGD,LabibM., 2008.The inter-operator variability in measuring waist circumference and its potential impact on the diagnosis of the metabolic syndrome,Postgrad Med J 84 344 -7

[6] KhanS,HafizullahM,FaheemM,NadeemM,ShahI,AsgharM, 2012.Level of` high sensitivity C-reactive protein in patients with chronic stable angina,J Med Sci 20 124 -7

[7] RichardN,FogorosMD, 2010.New guidelines on CRP testing: new recommendations from the AHA and ACC,Circulation 122 2748 -64

[8] AnuuradE,ShiwakuK,NogiA,KitajimaK,EnkhmaaB,ShimonoK, 2003.The new BMI criteria for Asians by the regional office for Western Pacific Region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers,J Occup Health 45 335 -43

[9] SheikhAS,YahyaS,SheikhNS, 2012.Sheikh A. C-reactive protein as a predictor of adverse outcomes in patients with acute coronary syndrome,Heart Views 13 7 -12

[10] MarjoleinV,LexMB,GeraldineMM,MarkHW,TamaraBH, 1999.Elevated C-reactive protein levels in overweight and obese adults,JAMA 282 2131 -5

[11] ThorandB,BaumertJ,DoringA,HerderC,KolbH,RathmannW, 2006.Sex differences in the relation of body composition to markers of inflammation,Atherosclerosis 184 216 -24

[12] LinCC,KardiaSL,LiC,LiuCS,LaiMM,LinWY, 2010.The relationship of high sensitivity C-reactive protein to percent body fat mass, body mass index, waist-to-hip ratio, and waist circumference in a Taiwanese population,BMC Public H 10 579 -

[13] HuG,JousilahtiP,ToumilehtoJ,AntikainenR,SundvallJ,SalomaaV, 2009.Association of serum C-reactive protein level with sex-specific type 2 diabetes risk: a prospective Finnish study,J Clin Endocrinol Metab 94 2099 -105

[14] CraigP,ColagiuriS, 2007.Identifying cut-points in anthropometric indexes for predicting previously undiagnosed diabetes and cardiovascular risk factors in the Tongan population,Obesity Res Clin Prac 1 17 -25

[15] ThimpsonNJ,LawlorDA,Harbord RM, 2005.C-reactive protein and its role in metabolic syndrome: Mendelian randomisation study,Lancet 366 1954 -2009

[16] GreenlandP,AlpertJS,BellerGA, 2010.ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: executive summary,J Am Coll Cardiol 56 2182 -99

[17] BergAH,SchererP, 2005.Adipose tissue, inflammation, and cardiovascular disease,Circulation 96 939 -49

[18] DesprésJP,LemieuxI., 2006.Abdominal obesity and metabolic syndrome,Nature 444 881 -7

[19] DesprésJP, 2007.Cardiovascular disease under the influence of excess visceral fat,Critical Pathways Cardiol 6 51 -9

[20] BergmanRN,KimSP,HsuIR,CatalanoKJ,ChiuJD,KabirM, 2007.Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk,Am J Med 120 S3 -S8

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