Effect of dietary supplementation of microbial dextran and inulin exopolysaccharides on metabolomics and microbiome of BALB/c mice models | [Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23 • 2023]

Author(s):

1. Iqra Jawad: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

2. Husam Bin Tawseen: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

3. Muhammad Irfan: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

4. Waqar Ahmad: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan; Department of Microbiology, AUST, Havelian, Abbottabad, Pakistan

5. Mujtabah Hassan: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

6. Fazal Sattar: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

7. Fazli Rabbi Awan: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

8. Shazia Khaliq: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

9. Nasrin Akhtar: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

10. Kalsoom Akhtar: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

11. Munir Ahmad Anwar: Industrial Biotechnology Division, NIBGE-C, PIEAS, Faisalabad, Punjab, Pakistan

Abstract:

Microbial exopolysaccharides (EPSs), having great structural diversity, have gained tremendous interest for their prebiotic effects. In the present study, mice models were used to investigate if microbial dextran and inulin-type EPSs could also play role in the modulation of microbiomics and metabolomics by improving certain biochemical parameters, such as blood cholesterol and glucose levels and weight gain. Feeding the mice for 21 days on EPS-supplemented feed resulted in only 7.6 ± 0.8% weight gain in the inulin-fed mice group, while the dextran-fed group also showed a low weight gain trend as compared to the control group. The blood glucose levels of the dextran- and inulin-fed groups did not change significantly compared to the control, which increased by 22 ± 5%. Moreover, the dextran and inulin exerted pronounced hypocholesterolemic effects by reducing the serum cholesterol levels by 23% and 13%, respectively. The control group was found to be mainly populated with Enterococcus faecalis, Staphylococcus gallinarum, Mammalii coccuslentus and Klebsiella aerogenes. The colonization of E. faecalis was inhibited by 59-65% while the intestinal release of Escherichia fergusonii was increased by 85-95% in the EPS-supplemented groups, respectively, along with the complete inhibition of growth of other enteropathogens. Additionally, higher populations of lactic acid bacteria were detected in the intestine of EPS-fed mice as compared to controls.

Page(s): 147-147

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023

Keywords:

hyperglycemia , hypercholesterolemia , Enteric Pathogens , prebiotic exopolysaccharides , gastrointestinal microbiota

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