The efficacy of combination of 20% azelaic acid with 0.05% tretinoin cream in the treatment of melasma | [Journal of Pakistan Association of Dermatologists • 2011]

Author(s):

1. MR Siddique: Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

2. L Khondker: Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

3. SC Hazra: Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

4. MSI Khan: Department of Dermatology and Venereology, Combined Military Hospital, Dhaka, Bangladesh

Abstract:

Background Melasma is a common acquired macular hyperpigmentation which involves mostly the sun exposed areas of face and neck. Objective To assess the efficacy of the combination of 20% azelaic acid with 0.05% tretinoin cream in the treatment of melasma. Patients and methods 30 patients of melasma were treated with daily night application of 20% azelaic acid and 0.05% tretinoin. Patients were assessed at 4, 8 and 12 weeks of treatment using melasma area severity index. Side effects during therapy were also noted. Results Majority i.e. 43% cases were between 26 to 30 years, 73.3% of patients were females and 56.7% were housewives, 70% were married and 86.7% were in middle class. Family history of melasma was positive in 66.7% cases. 93.3% patients had no history of systemic drug and 73.3% had no history of use of cosmetics. 93.3% of patients had malar area involvement and 6.7% had centrofacial area involvement. After treatment, the average MASI score decreased by 38.66% indicating moderate reduction of the severity of melasma. Burning sensation, itching and erythema developed in 50%, 30% and 16%, respectively. Conclusion The combination of 20% azelaic acid and 0.05% tretinoin cream in the treatment of melasma has a moderate lightening effect with some remarkable side effects.

Page(s): 265-269

DOI: DOI not available

Published: Journal: Journal of Pakistan Association of Dermatologists, Volume: 21, Issue: 4, Year: 2011

Keywords:

Melasma , 20 azelaic acid , 05 tretinoin

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