Goblet cell sialomucin, sulphomucin and O-acylated sialomucin content in ulcerative colitis. | [Proceedings of sheikh zayed postgraduate medical institute • 2004]

Author(s):

1. Bilquis A. Suleman: Department of Histopathology, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan

2. Ahsan-Ul-Wadood: Department of Histopathology, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan

3. Sabiha Riaz: Department of Histopathology, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan

Abstract:

This study was carried out to investigate the pattern of goblet cell sialomucin, sulphomucin and O-acylated sialomucin in ulcerative colitis. Endoscopic biopsy material was obtained from 15 cases of ulcerative colitis, and stained with High iron diamine / alcian blue and periodic acid borohydrate saponification PAS technique. The mucin profile was correlated with degree of dysplasia. Three (27.27 %) out of 11 cases without dysplasia and one (25 %) out of 3 cases with dysplasia showed increased sialomucin content. The content, of O-acylated sialomucin was normal in 66.66%and reduced in 33.33% of the cases. The reduction in the O-acylated sialomucin was seen in 75 % of the dysplastic lesions and in 18.18 % of the cases with no evidence of dysplasia. It can be concluded that composition of mucin is changed in ulcerative colitis. An increase in sialomucin and reduction in O-acylated sialomucin content was seen in some of the cases, the later change was associated more frequently with dysplasia.

Page(s): 31-34

DOI: DOI not available

Published: Journal: Proceedings of sheikh zayed postgraduate medical institute, Volume: 18, Issue: 1, Year: 2004

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