Abstract:
Degradation of drugs means instability of drug or loss of potency of drug which make it esthetically unacceptable. Knowledge of the stability of drug is fruitful to ensure drug stability and safety. Drug have diverse molecular structure and are therefore susceptible to many and variable degradation pathways including hydrolysis, isomerization, racemization, dehydration, elimination, oxidation, photo degradation by the effect of temperature, light, air, an aqueous medium or a solvent in which drug is dissolved. In this types drug molecules under goes the process of fragmentation or cleavage, thus concentration of drug going to decrease. But in second type there is complex interaction by excipients, dissolution medium or by the presence of buffer aqueous solutions of ions of various pH and thus here concentration of drug seems to increases due to ionization, salt formation, association of cation, or anion of compound, the salting out effects coming from the buffer used, the common ion effect, the equilibrium formation of different associates, self-association by forming mixed-charge micelles or micelle-like structures and possible aggregation of different species. The similar behavior is observed with drug rosiglitazonein the presences of different buffer ions species. Literature studies reveals that it is possible that change of pH, use of buffer, derivatization, complexation and salt formation will improve the solubility of drug. The present investigation reveals that rosiglitazone at elevated temperature interacts with solvent and buffer ions for instance ethanol, potassium, phosphate and borate and forms complex which may be accelerated its solubility or may retards drug absorption, distribution, elimination or may result in loss of potency and enhance the risk of toxicity.
Page(s):
115-115
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
thermal degradation
,
buffer
,
change of pH
,
complexion
,
Diverse molecular structure