Assessment of Antidepressant Potential of Zizyphus Nummularia in Sprague Dawley Rats Using Forced Swim Test | [First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book) • 2022]

Author(s):

1. Shumaila Jan: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad,Pakistan

2. Umbreen Rashid: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan;Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University,Pakistan;Department of Life Sciences, Abasyn University, Islamabad,Pakistan

3. Muhammad Rashid Khan: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University,Islamabad, Pakistan

4. Jasia Bokhari: Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University,Islamabad,Pakistan

5. Hammad Ismail: Department of Biochemistry and Biotechnology, University of Gujrat,Gujrat,Pakistan

6. Bushra Mirza: Lahore College for Women University,Lahore,Pakistan

Abstract:

Depression is a mental illness which causes high suicide rate and physical impairment as well. Currently, it is acknowledged as a major health issue. Therefore, it is very essential to search for novel therapeutic products for the cure of this ailment. Zizyphus nummularia belongs to the family Rhamnaceae. It is used for the cure of diabetes, as anti-inflammatory, antioxidant, anti-bacterial and fungal agent. Objectives: In the present investigation, antidepressant potentials of methanolic extract of Zizyphus nummularia were determined in Sprague Dawley rats using forced swim test. The rats were divided into three different groups (n=3). One group was kept as negative control while the other two groups were administered with flouxetin (10mg/10ml) and Zizyphus nummularia (400 mg/kg). Results: The results of this study have shown that methonolic extract of Zizyphus nummularia significantly reduced theimmobility time by 90.33 ± 32.86 seconds (P<0.05) in comparison to the immobility time of control i.e., 137.67 ± 6.11 sec. The decrease in the immobility time of standard was 37.00 ± 18.61 sec. Conclusion: The findings of this study are indicating the anti-depressant potential of Zizyphus nummularia which can be due to the presence of phytochemical compounds in it. This should be further investigated by isolating and identifying these compounds to use for drug formulation.

Page(s): 0-0

DOI: DOI not available

Published: Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022

Keywords:

forced swim test , Flouxetine , Zizyphus nummularia , antidepressant

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