The effect of pregabalin and gabapentin on preoperative anxiety and sedation: A double blind study. | [Anaesthesia, Pain and Intensive Care • 2012]

Author(s):

1. Anju Ghai: Department of Anaesthesiology, Pt B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

2. Monika Gupta: Department of Anaesthesiology, Pt B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

3. Neha Rana: Department of Anaesthesiology, Pt B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

4. Raman Wadhera: Department of ENT, Pt B.D.Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India

Abstract:

Background: Pregabalin and gabapentin are compounds, which have been alleged to possess anxiolytic, analgesic, and anticonvulsant properties. Both are amino acid derivatives of gamma amino butyric acid. Pregabalin has a similar pharmacological profile to that of gabapentin. It has an amino acid substitution at third position which allows better lipid solubility and diffusion across blood brain barrier, better pharmacokinetic properties and fewer drug interactions due to absence of hepatic metabolism. We hypothesized that premedication with oral pregabalin and gabapentin would produce dose-related reductions in acute (state) anxiety and increase in sedation (sleepiness) before induction of general anaesthesia. Methodology: 90 women were randomly assigned to receive 300 mg pregabalin and 900 mg gabapentin and placebo 60 minutes prior to surgery. Anxiety and sedation was assessed before administration of drug and 1 hour later. A uniform anaesthetic technique was used in all groups. Parameters including sedation scores and various side effects were assessed. Results: Demographic variables were comparable. The preinduction anxiety scores were statistically significant from the baseline values in group 1 and 11. The sedation scores were statistically significant 1 hour after the drug. There was statistically significant difference between group I and II (p=0.000), I and III (p=0.000) and II and III(p=0.015). Analysis of sedation scores after surgery were comparable at all time intervals between group I and II. However statistically significant difference was noted between group I and III (p=0.000) and group II and III (p=0.000). A higher percentage of patients in the pregabalin group complained of dizziness and somnolence than the gabapentin and control group. Conclusion: Preoperative pregabalin (300mg) and gabapentin (900mg) administration 1 hour before surgery led to significant reduction in preoperative anxiety and improves sedation without producing significant side effects.

Page(s): 257-261

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 16, Issue: 3, Year: 2012

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views