Abstract:
The incidence of skin fungal infections is increasing at an alarming rate worldwide, presenting a major challenge to health professionals. Cutaneous and subcutaneous fungal infections are caused by pathogenic or opportunistic organisms varying from mold, yeasts, to dimorphic fungi. The polymorphic fungus Candida albicans is a member of the normal human microbiome, and is more severe in immunocompromised patients of cancer. Increasing antimicrobial resistance is a clinical crisis worldwide. The increasing developments in nanotechnology will have intense impact on various areas of therapeutic applications, tissue engineering, and other applications. In this study we have synthesized and characterized Gold nanoparticles (AuNps) by XRD, FTIR and SEM to check the crystal structure, composition, crystalline grain size, for Surface composition and ligand binding,size and structural properties of AuNps respectively. Moreover, Gold nanoparticles have unique and tunable surface Plasmon resonance (SPR) with various applications in different fields of science especially in biomedical sciences and research, and to develop fungal mouse (C57/6) model of disseminated cutaneous candidiasis caused by injecting Candida albicans 5 × 106 cells/mlin to the subcutaneous layer of skin. This murine model would be used to the evaluate the first time in-vivo antifungal potential of AuNps prepared by various methods against subcutaneous fungal infections caused by C. albicans.
Page(s):
68-68
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
nanotechnology
,
Gold nanoparticles
,
subcutaneous fungal infections
,
fungal C albicans mouse model
,
onsite delivery