SYSTEMIC LUPUS ERYTHEMATOSUS; CORRELATION OF AUTOANTIBODIES WITH CLINICAL MANIFESTATIONS | [Journal of Postgraduate Medical Institute • 2020]

Author(s):

1. Belmokhtar Naima Rania: Molecular Microbiology,Proteomics and Health Laboratory,Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés,Algeria, Algeria.

2. Zemri Khalida: Molecular Microbiology,Proteomics and Health Laboratory,Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés,Algeria, Algeria.

3. Kanoun Khedoudja: Molecular Microbiology,Proteomics and Health Laboratory,Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés,Algeria, Algeria.

4. Harir Noria: Molecular Microbiology,Proteomics and Health Laboratory,Faculty of Natural and Life Sciences, Djillali Liabès University of Sidi Bel Abbés,Algeria, Algeria.

5. Bachaoui B.M: Department of Internal Medicine, Diabetes, Etablissement Hospitalier Universitaire d’ORAN - Algeria

6. Hebri Sid Tadj: Department Internal Medicine,University Hospital Centre CHU Dr. Hassani Abdelkader, Sidi Bel Abbes,Algeria.

Abstract:

To correlate positivity of auto-antibodies with clinical manifestations of systemic lupus erythmatosus in Algerian population. Methodology: This retrospective multicenter study was carried out on 203 Algerian patients with systemic lupus erythmatosus, diagnosed according to the American College of Rheumatology and SLICC criteria, from January 2006 to December 2019 in the University Hospital of ORAN region (EHUO) and the Abdelkader Hassani University Hospital of Sidi Bel Abbes region (CHU-SBA), west of Algeria. The study assessed the clinical characteristics and the profile of the auto-antibodies. The detection of antinuclear antibodies was carried out by indirect immune-fluorescence technique, anti- DNAn and anti-cardiolipin antibodies using immune-enzymatic technique and nuclear antigens extractable by immunodot. Results: The mean age of symptoms onset was 29.47 ± 11.24 years and the sex ratio of female to male was 9.68 : 1. The frequency of most clinical manifestations was 75.9%, 71.4% and 71.9% for rheumatological, dermatological and haematological disorders respectively. In total, about 25% of the cases had lupus nephropathy. The positivity of antinuclear antibody (ANA) was found in 94.8% of cases, anti-DNAn (66.1%), anti-Sm (32.7%), anti-RNP (21.8%), anti-SSA (38.5%) and anti-SSB (18.4%). A significant correlation was found between these auto-antibodies and clinical manifestations of SLE (p<0.05), in particular with anti-DNAn, anti-Sm, anti-RNP and anti-SSA. Conclusion: Anti-DNAn and anti-Sm antibodies strongly correlate with clinical manifestations and lupus nephropathy. The high frequency of anti-SSA antibodies in the Algerian population gives them a significant predictive value for the diagnosis of SLE.

Page(s): 259-266

DOI: DOI not available

Published: Journal: Journal of Postgraduate Medical Institute, Volume: 34, Issue: 4, Year: 2020

Keywords:

Systemic lupus erythematosus , Algeria , Autoantibodies

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