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Synthesis, Characterization, DFT Calculations and Anticoagulant Activity of Symmetrical and Unsymmetrical N-Aryl Thiourea Derivatives
Author(s):
1. Rekia Nabti: Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Bohammed’s University Bechar, Algeria
2. Nasser Belboukhari: Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Bohammed’s University Bechar, Algeria
3. Khaled Sekkoum: Bioactive Molecules and Chiral Separation Laboratory, Faculty of exact sciences, Tahri Bohammed’s University Bechar, Algeria
4. Noureddine Boulenouar: El-Bayadh University Center. Phytochemistry and Organic Synthesis Laboratory.
5. Houssem Boulebd: Laboratory of Synthesis of Molecules with Biological Interest, University of Frères Mentouri Constantine 1, Constantine, Algeria.
6. Salah Akkal: Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques. Université Constantine1, Route d’Aïn El Bey, 25000, Constantine, Algérie.
Abstract:
Summary: The present study reports a methodology for the synthesis of symmetrical and unsymmetrical thiourea derivatives 1-9, which have been prepared in good overall yields from condensation reactions between phenylisothiocyanate and different primary amines. The structures of all products were confirmed by the spectroscopic analysis (UV, IR, and NMR). These derivatives were tested for anticoagulant activity using PT and APTT reagents, and those reagents are considered also a controller, the results showed that the theN-aryl thiourea derivatives have very high anticoagulant activity. Theoretical calculations based on DFT/B3LYP method have been performed in order to get insights into the molecular geometry and chemical reactivity of the studied compounds.
Page(s): 81-92
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 46, Issue: 1, Year: 2024
Keywords:
Thiourea , Anticoagulant activity , APTT reagent , PT reagent , Phenylisothiocyanate
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