Typhoid Fever: Clinical experience with levofloxacin, its efficacy and safety. | [Professional Medical Journal • 2007]

Author(s):

1. Maqsood Ahmad: Department of Nuclear Medicine, Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan

2. Muhammad Saeed Akhtar: Department of Nuclear Medicine, Punjab Institute of Nuclear Medicine (PINUM), Faisalabad, Pakistan

3. Muhammad Amer Adil: DHQ Hospital Faisalabad, Pakistan

4. Badar Bashir: The Aga Khan University Hospital, Karachi, Pakistan

5. Muhammad Irfan: The Aga Khan University Hospital, Karachi, Pakistan

6. Zahid Yasin: Punjab Medical College, Faisalabad, Pakistan

Abstract:

To find out the efficacy and safety of Levofloxacin in patients suffering from typhoid fever. Design: Non-comparative and prospective study Setting: Medical Units of Allied & DHQ Hospital (PMC) Faisalabad, Period: From May 2002 to July 2004. Material & Methods: All suspected febrile patients were examined and provisionally diagnosed to have typhoid fever were admitted for the purpose of study till they were satisfactorily discharged. Results: This clinical study was conducted on 70 patients of Enteric Fever. Fifty-two patients were male and 18 were female. The mean age for male patients in the study sample was 37.58± 8.13 while the mean age of females was 21.92± 4.73 years. Fever as a symptom was present in all 70(100%) of the patients. Anorexia was there in 61 (85.5%) patients and abdominal pain in 49(70%) patients. Twenty-seven (38.5%) patients had constipation along with other features. Diarrhea was present in 6 (8.5%) patients. Relative bradycardia was present in 20(28.5%) patients. Hepa tomegaly was there in 31(44.3%) and Splenomegaly in 24(34.3%). Elevated liver enzymes were found in 29 (41.4%) of the patients and blood cultures positive for Salmonella typhi was seen in 19(27.1%) patients. Widal test was positive at dilution of 1:160 in almost all of the cases and at 1:320 dilution in 18% of cases in current study. The success rate of Levofloxacin in our study was 100% in the form of settlement of fever and other symptoms and signs. The side effects were seen in 17(24.2%) patients. Conclusions: In conclusion levofloxacin is effective in treatment of typhoid fever and its use in this indication is safe.

Page(s): 620-626

DOI: DOI not available

Published: Journal: Professional Medical Journal, Volume: 14, Issue: 4, Year: 2007

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