A simple and rapid approach to evaluate the in vitro in vivo role of release controlling agent Ethyl cellulose ether derivative Polymer. | [Pakistan Journal of Pharmaceutical Sciences • 2014]

Author(s):

1. Muhammad Akhlaq: Faculty of Pharmacy, Gomal University, D.I. Khan, KPK, Pakistan

2. Gul Majid Khan: Department of Pharmacy, Quaid-e-Azam University, Islamabad, Pakistan

3. Syed Umer Jan: Faculty of Pharmacy, University of Balochistan, Quetta, Pakistan

4. Abdul-Wahab: Faculty of Pharmacy, Gomal University, D.I. Khan, KPK, Pakistan

5. Abid Hussain: Faculty of Pharmacy, Gomal University, D.I. Khan, KPK, Pakistan

6. Asif Nawaz: Faculty of Pharmacy, Gomal University, D.I. Khan, KPK, Pakistan

7. Hamdy Abdelkader: Department of Pharmaceutics, Minia University, Egypt

Abstract:

Diclofenac sodium (DCL-Na) conventional oral tablets exhibit serious side effects when given for a longer period leading to noncompliance. Controlled release matrix tablets of diclofenac sodium were formulated using simple blending (F-1), solvent evaporation (F-2) and co-precipitation techniques (F-3). Ethocel® Standard 7 FP Premium Polymer (15%) was used as a release controlling agent. Drug release study was conducted in 7.4 pH phosphate buffer solutions as dissolution medium in vitro. Pharmacokinetic parameters were evaluated using albino rabbits. Solvent evaporation technique was found to be the best release controlling technique thereby prolonging the release rate up to 24 hours. Accelerated stability studies of the optimized test formulation (F-2) did not show any significant change (pmax=237.66±1.98) and extended the peak time (tmax=4.63±0.24). Good in-vitro in vivo correlation was found (R2 =0.9883) against drug absorption and drug release. The study showed that once-daily controlled release matrix tablets of DCL-Na were successfully developed using Ethocel® Standard 7 FP Premium.

Page(s): 1789-1798

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 27, Issue: 6, Year: 2014

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views