Abstract:
Biogenic synthesis of nanoparticles using plant extracts offer a sustainable andbiocompatible alternative to conventional chemical methods, with promisingapplications in therapeutic development. In this study, chromium nanoparticles(CrNPs) were synthesized using Adiantum capillus-veneris extract,characterized through various instrumental techniques and evaluated for theirantioxidant and antidiabetic potential in vitro. The optimal synthesis wasachieved at a 4:9 ratio of plant extract to chromium salt. The synthesized CrNPswere crystalline in nature, irregular to round in shape, with sizes ranging from58 to 90 nm, and thermally stable up to 280°C and exhibited strong absorbancepeak in UV-Vis range at 420 nm. The EDX analysis confirmed the presence ofchromium at ~0.6 keV. The CrNPs showed excellent antioxidant (DPPH, IC50 =100 µg/mL; ABTS, IC50 = 125 µg/mL) and notable inhibition of carbohydratehydrolyzingenzymes; a-amylase (91.3% inhibition at 1000 µg/mL, IC50 =127 µg/mL) and a-glucosidase (86.4% inhibition at 1000 µg/mL, IC50 =140 µg/mL). CrNPs exhibited stronger biological potentials and outperformedboth the aqueous and methanolic extracts of Adiantum capillus-veneris plant, aswell as chromium salt in employed antioxidant and antidiabetic tests. Inconclusion, the study suggests the potential utilization of CrNPs as therapeuticagent in curing diabetes and related complications which needs to be furthervalidated in experimental diabetic models. The observed synergistic effects offabricated CrNPs were higher than parental extracts and metal salt.
Page(s):
94-94
DOI:
DOI not available
Published:
Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025
Keywords:
Green synthesis
,
metal nanoparticles
,
Antioxidant assay
,
Phytochemical reduction
,
Plantmediated synthesis