The value of RACK1 and peripheral blood M2/M1 monocyte ratio on the prognosis of patients with oral squamous cell carcinoma | [Pakistan Journal of Pharmaceutical Sciences • 2023]

Author(s):

1. Hui Liu: Department of Dental, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China

2. Ran Wu: Department of Dental, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China

3. Lei Bi: Department of Dental, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China

4. Xiaoliang Xu: Tangshan Second Hospital, Tangshan, Hebei, China

5. Hui Chen: Department of Dental, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China

Abstract:

This study is to evaluate the effect of receptor for activated c kinase 1 (RACK1) and peripheral blood M2/M1 monocytes ratio on the prognosis of patients with oral squamous cell carcinoma (OSCC). A total of 115 OSCC patients who underwent radical surgery in North China University of Science and Technology Affiliated Hospital from January 2015 to December 2015 were included in the experimental group and 34 healthy individuals after a physical examination during the same period were included in the control group. Cancer and para-cancerous tissues were collected, and the relationship between RACK1 and M2/M1 ratio and the prognosis of OSCC patients and its predictive value were analyzed. RACK1, M2/M1 ratio, clinical stages, lymphatic metastasis, recurrence and metastasis were considered independent factors for the prognosis of OSCC patients (p<0.05); In addition, RACK1 and the M2/M1 ratio were proven to be of significant predictive values for the prognosis of OSCC patients (p<0.05). RACK1 and peripheral blood M2/M1 monocytes ratio demonstrate great potential as prognostic predictors of OSCC patients.

Page(s): 631-638

DOI: 10.36721/PJPS.2023.36.2.SP.631-638.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: S2, Year: 2023

Keywords:

prognosis , OSCC , RACK1 , M2M1 ratio

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