The effect of hydro alcoholic extract of Juglans regia leaves in streptozotocin-nicotinamide induced diabetic rats. | [Pakistan Journal of Pharmaceutical Sciences • 2012]

Author(s):

1. Jamshid Mohammadi: Herbal Medicine Research Center, Department of Physiology, College of Medicine, Yasouj University of Medical Sciences, Yasouj, Iran

2. Hamdollah Delaviz: Cellular and Molecular Center, Yasouj University of Medical Sciences, Yasouj, Iran

3. Jan Mohammad Malekzadeh: Herbal Medicine Research Center, Department of Nutrition, College of Health, Yasouj University of Medical Sciences, Yasouj, Iran

4. Amrollah Roozbehi: Cellular and Molecular Center, Yasouj University of Medical Sciences, Yasouj, Iran

Abstract:

Phytotherapy has been achieved to maintain glycemic control in patients with diabetes mellitus. The present study was conducted to evaluate the antihyperglycemic properties of the Juglans regia leaf extract in streptozotocinnicotinamide induced diabetic rats. Nicotinamide was injected intraperitonealy (i.p.) 15 min before the injection of Streptozotocin (i.p.). One week after induction of diabetes, oral treatment started with extract of Juglans regia and Metformin and continued for 4 weeks. Fasting blood sugar, body weight, serum lipids and insulin level were measured in different groups. A significant reduction of glucose, HbA1c, total cholesterol and serum triglycerides were detected after 4 weeks in rats treated with Juglans regia leaves compared to the control groups. Thus, Juglans regia extract treatment showed potential hypoglycemic and hypolipidemic effects in type 2 diabetic rats.

Page(s): 407-411

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 25, Issue: 2, Year: 2012

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