Butyrylcholinesterase inhibitory lignans from sarcostemma viminale. | [Proceedings of Pakistan Academy of Sciences • 2005]

Author(s):

1. Syed Raziullah Hussaini: Department of Chemistry, University of Kentucky, Lexington, KY 40506 USA

2. M. Iqbal Choudhary: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

3. Sarfraz A. Nawaza: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

4. Farzana Kousara: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

5. Muhammad Athar Abbasia: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

6. Muhammad Zubaira: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

7. Viqar Uddin Ahmad: HEJ Research Institute of Chemistry International Center for Chemical Sciences University of Karachi, Karachi, Pakistan

Abstract:

The investigation of the chemical constituents of Sarcostemma viminale led to the isolation of two lignans, pinoresinol (1) and 9α-hydroxypinoresinol (2), which are reported for the first time from this species alongwith β -sitosterol (3), β-amyrin (4), lupeol (5), oleanolic acid (6) and ursolic acid (7). The structures of the these compounds were determined by 1D and 2D- homonuclear and heteronuclear NMR spectroscopy, chemical evidences, and by comparison with the published data of these compounds. The pinoresinol 1 and 9α-hydroxypinoresinol 2 displayed in vitro inhibitory activity against butyrylcholinesterase (BChE) enzyme with IC50 value of (15.0 ± 0.1) and (275.1 ± 2.4) µM respectively.

Page(s): 167-171

DOI: DOI not available

Published: Journal: Proceedings of Pakistan Academy of Sciences, Volume: 42, Issue: 3, Year: 2005

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