1-(2,4-Dihydroxyphenyl)-1-ethanone hydrazone derivatives as notable butyrylcholinesterase inhibitors. | [Journal of Chemical Society of Pakistan • 2016]

Author(s):

1. Muhammad Athar Abbasi: Department of Chemistry, Government College University, Lahore-54000, Pakistan

2. Sikander Khan Niazi: Department of Chemistry, Government College University, Lahore-54000, Pakistan

3. Aziz-Ur-Rehman: Department of Chemistry, Government College University, Lahore-54000, Pakistan

4. Sabahat Zahra Siddiqui: Department of Chemistry, Government College University, Lahore-54000, Pakistan

5. Ghulam-Hussain: Department of Chemistry, Government College University, Lahore-54000, Pakistan

6. Shahid Rasool: Department of Chemistry, Government College University, Lahore-54000, Pakistan

7. Muhammad Ashraf: Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

8. Jamil Rahman: Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur-63100, Pakistan

9. Khalid Mohammed Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Abstract:

Azomethine group of Schiff bases is known to express valuable biological activities. 1- (2, 4-Dihydroxyphenyl)-1-ethanone N`-substituted hydrazone derivatives, 4a-s, were synthesized in multistep. The starting material 2, 4-dihydroxyacetophenone (1) was stirred with hydrated hydrazine to yield 1-(2, 4-dihydroxyphenyl)-1-ethanone hydrazone (2) which was further reacted with (un)substituted benzaldehydes, 3a-s, to acquire the target molecules, 4a-s. Moreover, the synthesized derivatives 4a-s was characterized via IR, EI-MS, 1H-NMR and 13C-NMR spectral techniques. Most of the compounds were found to be valuable inhibitors of butyrylcholinesterase enzyme.

Page(s): 106-114

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 1, Year: 2016

Keywords:

Keywords are not available for this article.

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views