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The relationship of oxidative stress and inflammatory response in females associated with endometriosis
Author(s)
Sumera Noor Department of Allied Health Sciences, The Superior University, Lahore, Pakistan
Tahir Muhammad Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan
Mateen-Ur- Rehman Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan
Bushra Sayyed Department of Gynaecology and Obstetrics, Sir Ganga Ram Hospital /Fatima Jinnah Medical University, Lahore, Pakistan
Shahid Noor Department of Allied Health Sciences, The Superior University, Lahore, Pakistan
Jan Ubaidullah Department of Allied Health Sciences, The Superior University, Lahore, Pakistan
Tahir Maqbool Institute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan
Rana Muhammad Athar Azeem Shams Department of Allied Health Sciences, The Superior University, Lahore, Pakistan
Abstract
Endometriosis is considered as a debilitating condition that is characterized by formation of endometrial tissue outside the uterus that consequently adversely impacts female fertility. Number of factors are involved that mediates the gynecological pathology of endometriosis, however the relationship of endometriosis with oxidative stress and inflammatory needs to investigate. In this study, we selected females of age 21-27 years associated with endometriosis and performed a detailed hematological profile. Our data indicated that the hematological profile of patients associated with endometriosis was highly disrupted compared to healthy control females. Number of hematological parameters including RBCs, WBCs, HB, platelets and overall bilirubin level was abnormal in endometritis patients. In addition, we also determined the level of oxidative stress by using the expression profile of different oxidant and antioxidant genes through spectrophotometric examination. We found elevated levels of MDA and reduced expressions of SOD, GSH, and CAT in patients associated with endometriosis relative to healthy patients that suggest the increased oxidative stress level. Furthermore, different vitamins including, Vit. A, Vit. C, VIit. E and Vit. D levels were also reduced in patients of endometriosis. Collectively, our data suggest that hematological profile and oxidative stress of patients associated with endometriosis was highly disruptive and these differential biomarkers may be useful to diagnose the endometriosis patients and also beneficial for developing treatment strategies.
Publication Details
Page(s) 345-350
DOI 10.31580/pjmls.v5i2.2523
Published Journal: Pak-Euro Journal of Medical and Life Sciences, Volume: 5, Issue: 2, Year: 2022
Keywords
RBCs Platelets oxidative stress hemoglobin Endometriosis Hematocrit WBCs
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