Utility of Spectroscopic Studies for Quantification of Cefditoren Pivoxil in Commercial Samples | [Journal of Chemical Society of Pakistan • 2021]

Author(s):

1. Salma Ali Al-Tamimi: Department of Chemistry, College of Science, King Saud University,P. O. Box 22452, Riyadh 11495, Saudi Arabia.

2. Norah Sultan Abdulaziz Al-Motlaq: Department of Chemistry, College of Science, King Saud University, P. O. Box 22452, Riyadh 11495, Saudi Arabia.

3. Fatma Ahmed Aly: Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy,Mansoura University, Mansoura, Egypt

Abstract:

Summary: The current study is devoted to suggest new simple spectrophotometric probes for the estimation and quantification of cefditoren pivoxil (CFP) either in authentic or in commercial samples. Three simple kinetic and derivatize sensitive spectrophotometric methods were established. Two kinetic techniques (method A) and (method B) were based on the estimation of CFP using the oxidation properties of alkaline potassium permanganate at ambient temperature and the relation between the reduction in the absorbance of KMnO4 and the added CFP were also investigated. The intensity of absorbance (A) of the colored MnO4- ions were recorded at wavelengths 610 and 525 NM for the two methods, respectively. Method C was based on derivatization of CFP with 1,2naphthoquinone-4-sulphonate reagent in a basic solution (pH=11) to produce an orange red colored solution exhibited the highest absorption peak (?max) at 411 nm. The proposed systems displayed linearity over the concentration ranges of 1.0-16.0, 1.0-10.0 and 0.5-7.0 µg mL-1.The suggested systems were validated obeying analytical methodology guidelines and the acceptance criteria for accuracy, precision, linearity, selectivity, and robustness were met in all cases.

Page(s): 417-428

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 43, Issue: 4, Year: 2021

Keywords:

Derivatization method , Cefditoren pivoxil , Commercial products , Kinetic spectrophotometry

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