Synthesis, Characterization and Antimicrobial Activity of Piperidine Derivatives. | [Journal of Chemical Society of Pakistan • 2019]

Author(s):

1. Shaista Zafar: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

2. Shamim Akhtar: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

3. Syed Imran Ali: Department of Applied Chemistry & Chemical Technology, University of Karachi, Karachi, Pakistan

4. Nausheen Mushtaq: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

5. Sabahat Naeem: Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Karachi, Pakistan

6. Mohsin Ali: Department of Chemistry & Chemical Technology, University of Karachi, Karachi, Pakistan

Abstract:

Summary: Synthesis of various piperidine derivatives having important biological and pharmacological potentials has been discussed in the past. In present study we reported the synthesis of benzoyl and sulphonyl derivatives by taking Piperidine-4-carboxamide as principal molecule. These compounds were characterized by various spectroscopic techniques such as NMR, FTIR and Mass spectrometry. Elemental composition was explored using CHN analyzer. Antimicrobial activity study of the synthesized compounds was performed using disc diffusion method. Dissociation constant (pKa) of the synthesized compounds were determined by potentiometric titration method. In addition. The findings of the study predicted good absorption of these newly synthesized compounds. Besides, compound III showed good antifungal activity which can be helpful in pharmacokinetics and pharmacodynamics approaches of antibiotics.

Page(s): 363-367

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 41, Issue: 2, Year: 2019

Keywords:

Keywords are not available for this article.

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