Aminoglycosides induced nephrotoxicicty and its protection by Nigella sativa. | [Journal of Cardiovascular Diseases • 2003]

Author(s):

1. Shahnaz Akhtar: Department of Pharmacology and Biochemistry, Fatima Jinnah Medical College, Lahore, Pakistan

2. Rukhshan Khurshid: Department of Pharmacology and Biochemistry, Fatima Jinnah Medical College, Lahore, Pakistan

3. Bushra Farooqi: Department of Pharmacology and Biochemistry, Fatima Jinnah Medical College, Lahore, Pakistan

Abstract:

The major obstacle limiting the use of aminoglycoside antibiotics has been and continues to be the possibility of drug induced ototoxicity and nephrotoxicity. Changes in biochemical parameters related to nephropathy before and after the use of gentamicin and nigella sativa was observed. Ten Rabbits were divided into two groups. Group I was given only gentamicin and its effects on kidney function were observed. Group II was given gentamicin and extract of Nigella Sativa for 11 days and the biochemical changes related to kidney function were estimated. It is suggested that although Nigella sativa shows a significant effect on nephrotoxicity induced by gentamicin but its effect on the level of serum calcium and cholesterol may be dangerous. However further research is needed on large number of rabbits to reach on a definite conclusion.

Page(s): 50-52

DOI: DOI not available

Published: Journal: Journal of Cardiovascular Diseases, Volume: 1, Issue: 1--2, Year: 2003

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