Author(s):
1. Badr Abdullah Aldahmash:
Zoology Department, College of Sciences, King Saud University,Riyadh,Saudi Arabia
2. Doaa M. El-Nager:
Faculty of Science and Humanity, Hotat bani Tamim, Salman University,Saudi Arabia
Abstract:
The present study was carried out to investigate the protective effect of vitamin C as antioxidant to reduce hepatotoxicity and spleen toxicity induced by lead. Lead acetate administered at 20 mg/kg intake caused severe alterations in liver and spleen manifested by hepatocytes degeneration and leucocytes infiltration and fibrosis in liver, ill-defined architecture and large macrophages in the spleen. Vitamin C administered at 500 mg/kg of vitamin C one hour prior to lead reduced hepatotoxicity but did not affect liver fibrosis. Moreover, Vitamin C reduced the toxicity in spleen characterized by well-defined spleen architecture.
Page(s):
1425-1431
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Zoology, Volume: 46, Issue: 5, Year: 2014
Keywords:
Lead
,
liver
,
Micevitamin C
,
Spleen
References:
References are not available for this document.
Citations
Citations are not available for this document.