A novel preparation of L-citrulline and L-homocitrulline. | [Journal of Chemical Society of Pakistan • 2012]

Author(s):

1. Gen Guang Jia: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

2. Yi Liu: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

3. You Guang Zheng: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

4. Ling Zhang: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

5. Ling Liu: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

6. Ling Shan Gou: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

7. Xue Mei Zhuang: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

8. Xin Ling: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

9. Cui Yin: School of Pharmacy, Xuzhou Medical College, 84 West Huaihai Road, Xuzhou, Jiangsu, China

Abstract:

L-citrulline was synthesized from L-ornithine monohydrochloride, which was treated with copper salt under alkaline conditions to protect a-NH2, followed by formylation of d-NH2 with carbamide, and the removal of copper ion via the combination with sulfides or organic acids to release L-citrulline in satisfactory yield. L-homocitrulline was prepared from L-lysine monohydrochloride with the same method. This new method has the advantages of being environmentally friendly and suitable for industrial production.

Page(s): 451-454

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 34, Issue: 2, Year: 2012

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