The relationship of 1,25-dihydroxyvitamin D and Vitamin D binding protein in periodontitis. | [Pakistan Journal of Medical Sciences • 2019]

Author(s):

1. Sara Rafique: Department of Physiology, Jinnah Medical & Dental College, 22-23, Shaheed-e-Millat Road, Karachi, Pakistan.

2. Mozaffer Rahim Hingorjo: Department of Physiology, Jinnah Medical & Dental College, 22-23, Shaheed-e-Millat Road, Karachi, Pakistan.

3. Mahparah Mumtaz: Department of Physiology, Jinnah Medical & Dental College, 22-23, Shaheed-e-Millat Road, Karachi, Pakistan.

4. Masood Anwar Qureshi: Department of Physiology, Dow University of Health Sciences, Karachi, Pakistan.

Abstract:

Objective: This study was conducted to explore the relationship between 1,25-dihydroxy vitamin D (1,25(OH)2D) and Vitamin-D binding protein (DBP) in patients with periodontitis and healthy controls. Methods: Seventy-five periodontitis cases were recruited from the dental OPD of Dow University of Health Sciences, Karachi. Diagnostic criteria of periodontitis were followed according to the probe pocket depth and clinical attachment loss. Seventy-five periodontal healthy controls were selected from the faculty and students of same university. Serum levels of 1,25(OH)2D and DBP were determined by ELISA. Results: Significantly low levels of 1,25(OH)2D and high levels of serum DBP were observed in periodontitis patients compared to healthy controls (p<0.05), with levels of DBP increasing significantly with the severity of periodontitis (p=0.005). Concentrations of DBP correlated positively with 1,25(OH)2D, especially in cases with periodontitis (r =0.780; p<0.001). Conclusion: Within the limits of the study, we conclude that low 1,25(OH)2D levels and high DBP levels are associated with periodontitis.

Page(s): 847-851

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 35, Issue: 3, Year: 2019

Keywords:

Periodontitis , Vitamin D binding protein

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