Allo-Imperatorin: A potent urease Inhibitor from fresh Unripe fruits of aegle marmelos (Rutaceae) | [Journal of Chemical Society of Pakistan • 2011]

Author(s):

1. Muhammad Shaiq Ali: H. E. J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi-75270, Pakistan

2. Ghafoor Ahmed: H. E. J. Research Institute Of Chemistry, International Center For Chemical And Biological Sciences, University Of Karachi, Karachi-75270, Pakistan

3. Muhammad Kashif Pervez: H. E. J. Research Institute of Chemistry, International Center for Chemical and biological Sciences, University of Karachi, Karachi-75270, Pakistan Pharmaceutical Research Center, Pakistan Council for Scientific & Industrial Research Laboratories Complex, Karachi, Karachi-75280, Pakistan

4. Mehreen Lateef: Pharmaceutical Research Center, Pakistan Council For Scientific & Industrial Research Laboratories Complex, Karachi, Karachi-75280, Pakistan

5. Nighat Afza: Pharmaceutical Research Center, Pakistan Council For Scientific & Industrial Research Laboratories Complex, Karachi, Karachi-75280, Pakistan

6. Lubna Iqbal: Pharmaceutical Research Center, Pakistan Council For Scientific & Industrial Research Laboratories Complex, Karachi, Karachi-75280, Pakistan

Abstract:

During the search for bioactive constituents from different parts of Aegle marmelos (Rutaceae), the ethanol soluble portion of fresh unripe fruits yielded two known amides named aegeline (1) and 2-O-methyl aegeline (2), and five known coumarins named xanthotoxol (3), allo-imperatorin (4), marmesin (5), marmin (6), 7¢-O-methylmarmin (7). Structures of 1-7 were elucidated with the aid of spectroscopic techniques. All the isolated constituents (1-7) were tested for urease inhibition. allo-Imperatorin was found the most potent among the all tested samples with the IC50 value 27.5 µM.

Page(s): 960-964

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 33, Issue: 6, Year: 2011

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