The Predictive Value of the Inflammatory Markers P-selectin and Mcp1 in Determining the Length of Stay and 30-day Survival in the Differentiation of Sepsis Patients. | Journal of Pakistan Medical Association 2018

Author(s)

Ali Duman Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

Kenan Ahmet Turkdogan Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

Mucahit Avcil Department of Faculty of Medicine, Adnan Menderes Universtiy, Aydin

Cigdem Yenisey Department of Biochemistry, Adnan Menderes Universtiy, Aydin

Mevlut Ture Department of Biochemistry, Adnan Menderes Universtiy, Aydin, Turkey

Ayhan Akoz Department of Biochemistry, Adnan Menderes Universtiy, Aydin

Bekir Dagli Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin

Mucahit Kapci Department of Emergency Medicine, Adnan Menderes Universtiy, Aydin

Serhat Orun Emergecy Service, Bandirma State Hospital, Balikesir, Turkey

Abstract

Objectives: Sepsis is the leading disease that is diagnosed late and still has a mortal course in emergency departments. The primary factors that will reduce both morbidity and mortality are early diagnosis and an early treatment approach. Therefore, in this study, P-selectin and MCP1 levels, which are known to be markers of inflammation, were examined in patients being followed up in intensive care. Methods: Patients evaluated with a preliminary diagnosis of sepsis in the emergency intensive care unit between September 2015 and August 2016 were classified as having sepsis or infection according to the Q- SOFA criteria, and the P-selectin values were compared. Results: In the sepsis group, GCS was determined as 13 (12-13), SBP 90 (80-110), tachypnea 24 (22-26), lactate 3.8 (0.6-16.0), MAP 70 (60-77), and LOS 16 days (9.5-20.3). In the ROC analysis, the sensitivity of P-selectin and MCP1 in the differentiation of patients with and without sepsis was 95.7%, and 73.8%, and the specificity was 97.8% and 73.8%, respectively. According to the cutoff values, the sensitivity and specificity in the prediction of patient mortality were 71.4% and 65.6% in P-selectin and 78.6% and 65.6% in MCP1. Conclusion: The P-selectin and MCP1 values in the emergency department can differentiate sepsis patients according to the Q-SOFA criteria and showed 30-day mortality at a significant level. Therefore, in patients with suspected sepsis in an emergency department, MCP1 can be of benefit to physicians in their decisions regarding LOS and transfer to intensive care.

Publication Details

Page(s) 1321-1326

DOI DOI not available

Published Journal: Journal of Pakistan Medical Association, Volume: 68, Issue: 9, Year: 2018

Keywords

Keywords are not available for this article.

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