The role of zinc on anti-newcastle disease virus specific antibody response and agranulocytes count in rabbits treated with methotrexate and prednisolone. | [Pakistan Journal of Pharmaceutical Sciences • 2012]

Author(s):

1. Muhammad Khalid Tipu: Lahore College of Pharmaceutical Sciences, 18-Km Raiwind Road, Lahore, Pakistan; Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan

2. Uzma Saleem: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

3. Khalid Hussain: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

4. Khushi Muhammad: Department of Microbiology, University of Veterinary and Animal Sciences, Lahore, Pakistan

5. Furqan Khurshid Hashmi: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

6. Muhammad Islam: Lahore College of Pharmaceutical Sciences, 18-Km Raiwind Road, Lahore, Pakistan

7. Bashir Ahmad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Abstract:

Zinc (Zn) plays a pivotal role in highly proliferative tissues including immune system. The long-term therapy of neoplastic and autoimmune disorders is associated with immunosuppression and myleosuppression. In the current study role of Zn on anti-Newcastle disease virus response and agranulocytes count of methotrexate and prednisolone treated rabbits. Thirty six healthy rabbits were randomly segregated into six groups (group I to VI) each containing six rabbits. Oil based Newcastle disease virus (NDV) vaccine was administered subcutaneously to rabbits of all the groups at day 0 and 21 and after one week, all the groups received Zn, (Zn + prednisolone), prednisolone, (Zn + methotrexate) methotrexate orally from day 7 to day 21, except the control. The serum antibody titer, total and differential leukocyte count were measured weekly for 6 weeks. The administration of zinc in combination with methotrexate showed same antibody titer as that of the control suggesting that Zn has ability to counteract the methotrexate-induced immunosuppression. However, Zn did not show any significant impact in combination with prednisolone (p<0.05). The results of the present study indicate that co-administration of Zn and methotrexate is beneficial in the activity of immune system.

Page(s): 845-849

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 25, Issue: 4, Year: 2012

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