Biological Activities of Isolated Phytochemicals from Selected Medicinal Plant Species and Their in Silico Analysis against Antiviral Proteins of Hepatitis 6var, Influenza 1ea3 and Sars Covid- 19 6lus | [Abstract Book on Second International Conference on Recent Approaches in Plant Sciences (RAPS-23) 4-5 May 2023 • 2023]

Author(s):

1. Ayesha Khanum: Department of Botany, PMAS-Arid Agriculture University Rawalpindi, Pakistan

2. Yamin Bibi: Department of Botany, PMAS-Arid Agriculture University Rawalpindi, Pakistan

3. Ghazala Mustafa: Department of Plant Sciences, Quaid-i-Azam University, Islamabad, Pakistan

4. Irum Khalid: Department of Botany, PMAS-Arid Agriculture University Rawalpindi, Pakistan

5. Neelum Naheed: Department of Botany, PMAS-Arid Agriculture University Rawalpindi, Pakistan

6. Abdul Qayyum: Department of Agronomy, The University of Haripur, Haripur 22620, Pakistan

Abstract:

Bioactive compounds are secondary metabolites of plants. They offer diverse pharmacological properties. Selected medicinal plants are known to have anticancer, antiviral, antioxidant, cytotoxic and antifungal effects. Present study was designed to study pharmacological profile of active compounds purified from selected species. The aim of this study was to consider antioxidant, antibacterial, cytotoxic and molecular docking of purified compounds from medicinal plants. DPPH and ABTS assay were applied for assessment of antioxidant properties of compounds. Antibacterial properties of compounds were checked by agar well diffusion method. Brine shrimp lethality assay was performed to check cytotoxic effect of compounds. Molecular docking was conducted to investigate the binding efficacy between isolated compounds and targeted proteins. The compound isomangiferrin and tiliroside presented strong antioxidant potential in DPPH assay while harmaline showed in ABTS assay. The compound harmine and harmaline exhibited highest zone of inhibition against Xanthomonas while Irriflophenone-3-C-ß- D-glucopyranoside showed maximum zone of inhibition against E. coli. Highest cytotoxic effect observed by compound tiliroside. The compound tiliroside showed the best binding mode of interaction to all targeted proteins presenting maximum hydrophobic interactions and hydrogen bonds. Bioactive compounds are significant source of natural antioxidants, which could help to prevent the progression of various diseases caused by free radicals.

Page(s): 62-62

DOI: DOI not available

Published: Journal: Abstract Book on Second International Conference on Recent Approaches in Plant Sciences (RAPS-23) 4-5 May 2023 , Volume: 0, Issue: 0, Year: 2023

Keywords:

antioxidant , Anticancer , bioactive compounds , medicinal plant

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