Abstract:
Objective The purpose of the study was to determine the impact of mild to moderate acne vulgaris on quality of life (QoL) and to assess the effect of oral doxycycline and topical 5% benzoyl peroxide treatment on QoL. Patients and methods One hundred patients, of either sex, suffering from mild to moderate acne vulgaris, were asked to fill the Dermatology Life Quality Index (DLQI) pro forma (Urdu and English version) independently before starting the treatment. The total score ranged from 0-30. The higher the score, the greater was the impact on QoL. All the patients were subjected to oral doxycycline 100 mg daily and were asked to apply 5% benzoyl peroxide once daily. Patients used these medicines for a period of three months, after which they were again asked to fill the DLQI pro forma. The data were analyzed after compiling the results. Results The results of 100 patients, who completed the study, were compiled. The mean age of patients was 20.45±3.27 years. Among 20 male patients, 8 suffered from grade 1 and 12 from grade 2 acne. Among 80 female patients, 9 suffered from grade 1 and 71 from grade 2 (p=0.012), showing a significant association between grading of acne with respect to gender of the patient. The disease was notably severe among females. Duration and progression of disease showed no significant effect on QoL. Before treatment, the mean DLQI score for females was 14.05±6.32 with minimum score of 1 and maximum score of 25. The mean score for male patients was 12.63±6.46 with minimum score of 1 and maximum of 26, showing that QoL is worse among females as compared to males. The mean pretreatment score was 12.92± 6.43. The score dropped to 5.34±3.14 (p=0.000) after treatment showing that there is a significant improvement in quality of life of these patients. Conclusion The study shows that mild to moderate acne vulgaris has a very large effect on the quality of life of our patients with significant psychosocial limitations. The combination treatment of oral doxycycline and topical 5% benzoyl peroxide significantly improves the quality of life in acne patients.
Page(s):
173-179
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Association of Dermatologists, Volume: 23, Issue: 2, Year: 2013