Bioactive Compounds via in vitro Culture Approach and Pharmacological Attributes of Genus Euphorbia: A Comprehensive Review | [Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences • 2023]

Author(s):

1. Noor Zaman: Department of Botany, University of Peshawar,Peshawar 25120,Pakistan

2. Sami Ullah: Department of Botany, University of Peshawar,Peshawar 25120,Pakistan

3. Wadood Shah: Department of Botany, University of Peshawar,Peshawar 25120,Pakistan

4. Muhammad Nauman Khan: Biology Laboratory, University Public School, University of Peshawar, Peshawar 5120, Pakistan; Department of Botany, Islamia College Peshawar, Peshawar 25120, Pakistan

5. Baber Ali: Department of Plant Sciences, Quaid-i-Azam University,Islamabad 45320,Pakistan

6. Amjad Ali: Department of Sustainable Crop Production, Universita Cattolica del Sacro Cuore,Via Emilia, Parmense 84,Italy

7. Fethi Ahmet Ozdemir: Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University,12000, Bingol,Turkey

8. Gaweł Sołowski: Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University,12000, Bingol,Turkey

Abstract:

The family Euphorbiaceae comprises 2000 species and is listed as third among the largest flowering family. Euphorbia is used in traditional treatment for various diseases, including dengue fever, dysentery, diarrhea, and anemia. This review aims to collect data from various published literature sources for quick and efective cultivation of Euphorbia species through tissue culture and documentation of potent secondary metabolites obtained from diferent cultures of Euphorbia and its manifold pharmacological activities from various parts extracts. The data for this review were systematically collected from diferent scientific databases, including Google Scholar, Science Direct, PubMed, and published literature. Diferent secondary metabolites have been reported from the in votro culture of Euphorbia containing anthocyanin, saponins, tannins, sterols, flavonoids, glycosides, diterpenes, and sesquiterpene. The essential oils from extractions of the Euphorbia genus embraced about 80 active phytochemical constituents. The extracts and compounds exhibited diferent pharmacological activities, including hepato-protective, anti-fungal, anti-bacterial, and anti-cancer. Besides the pharmaceutical and importance of the genus Euphorbia, this report also described the methodologies of explant cultures, in-vitro production of biologically active compounds, and vital phytochemicals extraction from various parts of Euphorbia. Therefore, there is great attention for in-vivo studies on Euphorbia to further investigate and confirm their therapeutic efects for safe and efective medical use. The in-vitro cultivation technique needs further development, either in bioreactors or temporary immersions and shakes flasks to obtain vigorous sprouts of Euphorbia.

Page(s): 565-584

DOI: 10.53560/PPASB(60-4)874

Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 60, Issue: 4, Year: 2023

Keywords:

biological activities , Bioactive compounds , Euphorbia , Disease Treated , Essential Phytoconstituents , Pharmacological Relevance

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