A comparative study of the effect of parentral and oral glutamine on biochemical parameters and on the duration of ICU stay in critically ill patients. | [Anaesthesia, Pain and Intensive Care • 2013]

Author(s):

1. Dinesh Singh: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

2. Sulekha Saxena: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

3. Jai Shree Bogra: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

4. Ajay Kr. Chaudhary: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

5. Girish Chandra: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

6. Shashi Bhushan: Department of Anesthesiology, King George’s Medical University Lucknow (UP), India

Abstract:

Objective: To study the comparative effects of parenteral and oral glutamine therapy on biochemical parameters and reduction in the hospital stay of critically ill patients. Study design: Randomized controlled trial. Methodology: 120 critically ill patients aged 16-60 years admitted to Trauma Ventilatory Unit, Trauma centre King George Medical University, Lucknow. The patients were randomly divided into 3 equal groups, 40 in each group: Group A (control group) received no glutamine; Group B received oral glutamine 20 g/d for 5 days and Group C received l-alanyl-l-glutamine dipeptide 0.3 g/kg/d by intravenous infusion for 5 days. Complete blood count was done at regular intervals of 24 hours. Total proteins and serum albumin were recorded at 5 day intervals. Single blinding was done. Results: The total leukocyte counts (TLC) levels in all the three groups increased after the treatment and the observed increase was least evident in Group C (18.7%), followed by Group B (32.5%) and it was the highest in Group A (38.2%). A similar observation was made for CRP and lymphocyte levels in all of the three groups. However, a significant decrease was found in total protein and albumin levels. The mean duration of hospital stay of Group C was the least followed by Group B and Group A. Conclusion: Parenteral glutamine in a dose of 0.3 g/kg/d was more efficacious than 20 g/d oral glutamine in increasing/decreasing in the biochemical parameters after the therapy. The duration of hospital stay was similar in all the groups after treatment.

Page(s): 123-127

DOI: DOI not available

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 17, Issue: 2, Year: 2013

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