Antibiotic activity of n-alkyl and cycloalkyl esters of L- alanine. L-valine and L-methionine hydrochloride. | Pakistan Journal of Pharmacy 1990

Author(s)

Z. A. Malik Quaid-e- Azam University, Islamabad, Pakistan

Farieha Elgetlavi Chemistry Department, Faculty of Science, Garyounis University, Benghazi, Libya

Awad Elhus-Sadi Chemistry Department, Faculty of Science, Garyounis University, Benghazi, Libya

Inamulhaq National Institute of Health, Islamabad, Pakistan

Abstract

N-alyl amino acid esters (C-1 to C-7) of L-alanine, L- valine and L-methionine hydrochloride have shown increase in their antimicrobial action with linear increase in the carbon of alkyl ester group. Their cyclic analogues were less active. Steric bulk at the -carbon of the amino acid also effect the activity. Comparative studies made against ampiclox, cephaloridine, penicillin V nove and vibramycine with Proteus, Pseudomonas, Klebsella and S. citreus. Results of screening for inhibition of growth are reported and discussed. Surface tension of 2% aqueous solutions of the esters are also reported.

Publication Details

Page(s) 17-22

DOI DOI not available

Published Journal: Pakistan Journal of Pharmacy, Volume: 3, Issue: 1--2, Year: 1990

Keywords

Keywords are not available for this article.

References

References are not available for this document.

Citations

Citations are not available for this document.