Synthesis, characterization, crystal structures, analgesic and antioxidant activities of Thiourea derivatives. | [Journal of Chemical Society of Pakistan • 2016]

Author(s):

1. Mohammad Shoaib: Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

2. Shafiullah : Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

3. Muhammad Ayaz: Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

4. Muhammad Nawaz Tahir: Department of Physics, University of Sargodha, Sargodha, Pakistan

5. Syed Wadood Ali Shah: Department of Pharmacy, University of Malakand, Chakdara Dir Lower, Khyber Pakhtunkhwa, Pakistan

Abstract:

1-(2-chlorobenzoy1)-3(2,3-dimethyl-5-oxo-l-phenyl-2,F-dihydro-1H-pyrazo1-4-yl) thiourea (Cl2AAP) and 1-(2-chlorobenzoyl)-3-(pyridine-2-yl)thiourea (Cl2AP) were synthesized and characterized by spectroscopic methods (FT-IR, 1H NMR) and single crystal X-ray diffraction. Both compounds crystallized in monoclinic system and solved in P21/n, Z = 4 and P21/C, Z = 12 space groups respectively. Pharmacological screenings of the synthesized compounds have shown comparable analgesic activity to that of the standard diclofenac sodium at 30 mg/kg body weight dose. The DPPH and ABTS free radical scavenging activity of Cl2AAP are more significant than Cl2AP as compared to standard (IC50= 10, 60; 45, 75; and

Page(s): 479-486

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 38, Issue: 3, Year: 2016

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