The objective of this study was to determine the prevalence of Helicobacter pylori infection in different age and sex group with associated degree of inflammation and effects of different staining methods in our settings. We studied 1 1 1 consecutive endoscopic biopsies over a period from March 1996 to August 1996. The presence or absence of H. pylori was tabulated according to age and sex of the patients. Thirty-Nine (35%) of 111 patients were positive for H. pylori. There were 56 males, among whom 17 (43.58%) were positive. There were 55 females, among whom 22 (56.42%) were positive for H. pylori. The presence of H. pylori in various age group was as follows: 21-30 years, 27.77%; 31-40 years, 38.88% 41-50 years, 27.77% and above 51 years, 13.88%. Reading the degree of inflammation, 8 (20.15%) patients showed mild degree of inflammation, 27 (69.23%) showed moderate degree of inflammation and 4 (10.25%) showed serve degree of inflammation. Regarding staining methods for evaluation of H. pylori, 33 patients (84.61%) showed positivity for H. pylori on Haematoxylin and Eosin staining and 39 (100%) showed positivity for H. pylori on Giemsa staining method.