A cup-like structure: synthesis, crystal structure and anti-cancer activity of 2-(2-(4,5-diphenyl-1H-imidazol-1-yl)acetamido)ethyl adamantane-1-carboxylate. | [Journal of Chemical Society of Pakistan • 2014]

Author(s):

1. Zhi-Qiang Cai: School of Petrochemical Engineering, Shenyang University of Technology, Liaoning, China

2. Ju Liu: College of Pharmacy, Liaoning University, Shenyang, Liaoning, China

3. Ming-Xiang Shao: Department of pharmacy, Tianjin Medical University, Tianjin, China

4. Yang Wang: College of Pharmacy, Liaoning University, Shenyang, Liaoning, China

5. Mei-Rong Zhang: College of Pharmacy, Liaoning University, Shenyang, Liaoning, China

6. Ye Chen: College of Pharmacy, Liaoning University, Shenyang, Liaoning, China

7. Li-Feng Xu: College of Pharmacy, Liaoning University, Shenyang, Liaoning, China

8. Min Gong: State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research, Tianjin, China

Abstract:

A new 4,5-diaryl-1H-imidazole compound, C30H33N3O3, was synthesized and then its crystal structure was determined by single crystal X-ray diffraction. The crystal symmetry is monoclinic, space group P21/c, with a = 9.0395 (18) Å, b =21.726 (4) Å, c = 13.042 (3) Å, α = 90°, β= 93.30° (3), γ = 90°, V = 2557.0 (9)Å3, Mr = 483.59, Z = 4. Data suggested the conformation of this compound was cup-like by generating centro-symmetric dimers through two N–H···N hydrogen bonds interactions and intermolecular π-π interaction. The anti-cancer activity of this compound showed significant anti-cancer activity.

Page(s): 717-722

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 36, Issue: 4, Year: 2014

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