Author(s):
1. Huseyin Gunizi:
Department of Otolaryngology, Alku Alanya Educat1on and Research Hospital,Antalya,Turkey
2. Hasan Basri Savas:
Department of Medicinal Chemistry, Alku Alanya Educat1on and Research Hospital,Antalya,Turkey
3. Sibel Genc:
Department of Medicinal Chemistry, Alku Alanya Educat1on and Research Hospital,Antalya,Turkey
Abstract:
Objective: To investigate the relationship between complaints and serum trace elements and oxidative stress levels in pediatric patients with allergic rhinitis (AR). Study Design: Descriptive study. Place and Duration of Study: Department of Otolaryngorhinology, Medicine Faculty, Alanya Alaaddin Keykubat University, between May and September 2020. Methodology: Thirty- ve patients diagnosed with AR in the pediatric age group and 35 healthy control groups were examined. The patients were evaluated according to the ARIA (Allergic rhinitis and its 1mpact on asthma) guidelines. Blood samples were taken during the attack to measure serum Zn and Cu levels and oxidative stress levels from patients diagnosed with AR. Measurements of serum Zinc and Copper levels, and recently developed new generation oxidant-antioxidant balance markers were performed spectrophotometrically using a commercial kit.] Results: The mean ages of the study patients and healthy controls were 10.9 ± 4.7 and 10.5 ± 4.9 years, respectively. Female/Male ratio was 20 (57.1%)/15 (42.9%) in both groups. Zn level was lower in the patient group (p <0.05). Total thiol and native thiol values were higher in the control group (p <0.05). Statistically signi cant high disul de values were found in allergic patients (p <0.05). Conclusion: Oxidative stress plays a role in the pathophysiology of allergic rhinitis, and thiol-disul de hemostasis may be an indicator in allergic rhinitis.
Page(s):
324-328
DOI:
DOI not available
Published:
Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 32, Issue: 3, Year: 2022
Keywords:
Oxidative stress
,
allergic rhinitis
,
Thiol
,
Disul de
References:
References are not available for this document.
Citations
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