A lignan with glucose uptake activity in 3T3-L1 adipocytes from the stem bark of Knema patentinervia | Pakistan Journal of Pharmaceutical Sciences 2017

Muhammad Taher Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Mohamed Zaffar Ali Mohamed Amiroudine Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Juliana Md Jaffri Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Mohamad Shahreen Amri Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Deny Susanti Department of Chemistry, Faculty of Science, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Shafida Abd Hamid Department of Chemistry, Faculty of Science, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Mohamad Fazlin Rezali SIRIM Berhad (National Metrology Laboratory),Lot PT, Bandar Baru Salak Tinggi, Sepang, Selangor,Malaysia

Choudhury Mahmood Hassan Manarat International University,Road No 106, Gulshan-2, Dhaka,Bangladesh

Roger W Read The School of Chemistry, The University of New South Wales,UNSW Sydney NSW,Australia

Qamar Uddin Ahmed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia,Jalan Istana, Bandar Indera Mahkota, Kuantan, Pahang,Malaysia

Farediah Ahmad Department of Chemistry, Faculty of Science,Universiti Teknologi Malaysia, Skudai, Johor,Malaysia

A new naturally occurring dibenzylbutyrolactone lignan named isocubebinic ether has been isolated from Knema patentinervia. The structure was established by spectroscopic methods, which include Ultraviolet, Infrared, Nuclear Magnetic Resonance and Mass Spectrometry. The compound showed activity in the stimulation of glucose uptake by 3T3-L1 adipocytes.