ANTI-INFLAMMATORY ACTIVITY OF TARAXEROL ACETATE | Journal of Medical Science 2016

Author(s)

Ubaid ur Rahman Department of Biochemistry, Khyber Medical College,Peshawar,Pakistan

Sobia Ali Department of Biochemistry, Khyber Medical College,Peshawar ,Pakistan

Ubaidullah Department of Biochemistry, Khyber Medical College,Peshawar ,Pakistan

Inamullah Khan Department of Pharmacy, University of Peshawar ,Pakistan

Mudassir Ahmad Khan Department of Biochemistry, Khyber Medical College,Peshawar ,Pakistan

Saatea Arif Department of Biochemistry, Khyber Medical College,Peshawar ,Pakistan

Saif ur Rahman Wazir Department of Biochemistry, Khyber Medical College,Peshawar,Pakistan

Abstract

Objectives: To investigate the anti- inflammatory effect of Taraxerol acetate, a pentacyclic triterpene isolated from the aerial parts of Artemisia roxburghiana. Material and Methods: The plant materials were shade dried and ground into powder which was extracted 3 times by soaking with 24 L of methanol for two weeks. Preliminary fractionation of the crude extract, obtained from combine extract, was done by using solvents of increasing polarity: hexane, chloroform, ethyl acetate and n-butanol. The ethyl acetate fraction was subjected to silica gel column chromatography with hexane to yield taraxerol acetate. The structure of isolated compound was confirmed by comparing their corresponding NMR and mass spectral data with those previously reported. Carregeneen induced paw edema model was used to carry out the anti- inflammatory activity of Taraxerol acetate in Wistar adult rats. Results: TA significantly (P< 0.05) reduced the edema induced by carrageenan at a dose of 60 mg/Kg body weight when measured both at 3h and 5h. Conclusion: Taraxerol acetate has a significant anti-inflammatory effect in addition to its gastroprotective effect making it a safer anti-inflammatory agent.

Publication Details

Page(s) 216-219

DOI 10.1186/s12906-015-0868-0

Published Journal: Journal of Medical Science, Volume: 24, Issue: 4, Year: 2016

Keywords

Antiinflammatory Taraxerol acetate Artemisia roxburghiana paw edema model

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