Objective: To determine whether lactate dehydrogenase (LDH), platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and lymphocyte-monocyte ratio (LMR) values can be used as a prediction for their relationship with stroke volume (SV) and for in-hospital mortality in stroke patients in Emergency Department (ED). Study Design: Analytical study. Place and Duration of Study: Balikesir University, Turkey from 24/03/2021 to 30/06/2021. Methodology: Patients aged 18 years or older, diagnosed with stroke in ED, were included in the study. Stroke volumes were calculated from di usion-weighted images (DWi) with 3D slicer software using image-based semi-automatic and manual segmentation methods. Results: Of the 265 patients, 128 (48.3%) were males. SV was signi cantly higher in the non-survivor group than in the survivor group (p=0.007). NLR was signi cantly higher in the non-survivor group than in the survivor group (p=0.018). Conclusion: The ratios of NLR and SV stand out as practical parameters for the estimation of mortality, prognosis, and management of patients diagnosed with acute stroke. Taking into account, these parameters in the diagnosis process and prognosis management in EDs will provide convenience.