Synthesis, spectral analysis and antibacterial activity of some novel 5- substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4- Oxadiazole derivatives. | [Pakistan Journal of Pharmaceutical Sciences • 2018]

Author(s):

1. Asia Siddiqa: Department of Chemistry, Government College University,Lahore,Pakistan

2. Muhammad Athar Abbasi: Department of Chemistry, Government College University,Lahore,Pakistan

3. Sabahat Zahra Siddiqui: Department of Chemistry, Government College University,Lahore,Pakistan

4. Samreen Gul Khan: Department of Chemistry, Government College University,Faisalabad,Pakistan

5. Shahid Rasool: Department of Chemistry, Government College University,Lahore,Pakistan

6. Syed Adnan Ali Shah: Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam,Selangor Darul Ehsan, Malaysia, Atta-ur-Rahman Institute for Institute for Natural Products Discovery (AuRIns), Universiti Teknologi MARA, Puncak Alam Campus,42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia

7. Aziz ur Rehman: Department of Chemistry, Government College University, Lahore, Pakistan

Abstract:

A number of novel 5-substituted-2-((6-bromo-3,4-methylenedioxybenzyl)thio)-1,3,4-Oxadiazole derivatives (6a-l) have been synthesized to evaluate their antibacterial activity. Using aryl/aralkyl carboxylic acids (1a-l) as precursors, 5-substituted-1,3,4-Oxadiazol-2-thiols (4a-l) were yielded in good amounts. The derivatives, 4a-l, were subjected to electrophilic substitution reaction on stirring with 6-bromo-3,4-methylenedioxybenzyl chloride (5) in DMF to synthesize the required compounds. All the synthesized molecules were well characterized by IR, 1H-NMR, 13C-NMR and EIMS spectral data and evaluated for antibacterial activity against some bacterial strains of Gram-bacteria. The molecule, 6d, demonstrated the best activity among all the synthesized molecules exhibiting weak to moderate inhibition potential.

Page(s): 1783-1790

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 31, Issue: 5, Year: 2018

Keywords:

Antibacterial activity , spectral analysis , carboxylic acids

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views