Synthetic N-[(substitutedsulfamoyl)phenyl]acetamides as moderate chymotrypsin inhibitors | [Pakistan Journal of Pharmaceutical Sciences • 2017]

Author(s):

1. Sabahat Zahra Siddiqui: Department of Chemistry, Government College University,Lahore,Pakistan

2. Anam Zahid: Department of Chemistry, Government College University,Lahore,Pakistan

3. Muhammad Athar Abbasi: Department of Chemistry, Government College University,Lahore,Pakistan

4. Aziz-ur-Rehman: Department of Chemistry, Government College University,Lahore,Pakistan

5. Faiz-ul-Hassan Nasim: Department of Chemistry, The Islamia University of Bhawalpur,Bhawalpur,Pakistan

Abstract:

A facile method has been implemented for the synthesis of different N-substituted sulfamoylacetamides by reacting 4-acetamidobenzenesulfonyl chloride (1) with different alkyl/aralkyl/aryl amines (2a-q) in basic aqueous media under controlled pH to afford -[(Substitutedsulfamoyl) phenyl]acetamides (3a-q) which were confirmed through spectral analysis like FT-IR, EIMS and 1H-NMR. Moreover, the synthesized derivatives were screened against a-Chymotrypsin. The enzyme inhibitory results revealed that most of the synthesized compounds were found to be moderate enzyme inhibitors.

Page(s): 675-681

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 30, Issue: 3, Year: 2017

Keywords:

NSubstitutedsulfamoyl phenyl acetamides , spectral characterization , 4Acetamidobenzenesulfonyl chloride , alkylaralkylaryl amines , aChymotrypsin and Enzyme inhibitory analysis

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