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A comprehensive review of the antithrombotic potential of propolis: insights into the therapeutic properties of bee glue
Author(s):
1. Kamal Ali Ahmed Attia: Department of Biology, Al-Jamoum University College, Umm-Al-Qura University, Makkah 25351, Saudi Arabia
Abstract:
Propolis, aresinous substance produced by bees, has garnered attention for its potential as a natural antithrombotic agent due toits rich composition of bioactive compounds. This review exp ltheotrhereapesutic effects of propolis, specifically focusing onits abilit yto inhibit platelet aggregation, promote fibrinolysis and regulate hemostatic balance. The study reviews various experimental models and clinical studies that assess the antithrombotic potential of propolis. It was found that propolis exerts significant effects by targeting multiple pathways involved in thrombus formation and clot resolution. Specifically, it inhibits excessive platelet activation, enhances fibrinolysis and maintains hemostatic balance. Additionally, the antioxidant and anti-inflammatory properties of propolis help reduce oxidative stress and systemic inflammation, both of which are linked to thrombosis. Key findings include the inhibition of platelet aggregation and enhancement of clot breakdown, supporting propolis as a promising natural alternative for thrombotic prevention and management. Propolis demonstrates significant potential as a natural adjunct to conventional antithrombotic therapies. Its multifaceted therapeutic actions, antithrombotic, antioxidant and anti-inflammatory, make it a promising candidate for reducing thrombosis risk. Propolis could become an important addition to current strategies for preventing and managing thrombotic disorders.
Page(s): 204-209
Published: Journal: Pakistan Journal of Biological Sciences, Volume: 28, Issue: 4, Year: 2025
Keywords:
bioactive compounds , Propolis , Fibrinolysis , blood clotting , Glue , platelet activity
References:
[1] Favaloro L.,Pasalic G.,Lippi G. .2023 .. , : .
[2] Hemostasis ,R.C. . .Thrombosis: An Overview Focusing on Associated Laboratory Testing to Diagnose and Help Manage Related Disorders. In: Hemostasis and Thrombosis: Methods and Protocols, (1) : 3-38.
[3] May JE,Lim M. .2021 .Disorders of fibrinogen and fibrinolysis. Hematol. Oncol. Clin. N. Am., 35 : 1197-1217.
[4] Wang M,Zhu L. .2018 .Thrombotic regulationfromtheendothelial cell perspectives. Arterioscler., : .
[5] Thromb. Vasc. Biol. . .. , 38 : 90-e95.
[6] Lacey H.,Rehman R.,Puri D.L.,BhattandA. Kalra D.L. .2020 .Coronary embolism: A systematic review. Cardiovasc., : .
[7] Med Revascularization . .. , 21 : 367-374.
[8] Batten L.,Sathyapalan T.,Palmer T.M. .2023 .Molecular mechanisms linking diabetes with increased risk of thrombosis. Int. J. Mol. Sci,, 24 : .
[9] Said Al,S Al,Bode C.,Duerschmied D. .2018 .. , : .
[10] Hamostaseologie . .. , 38 : 240-246.
[11] Makedonov S.R.,Kahn J.P.,Galanaud J.P. .2020 .Prevention and management of the post-thrombotic syndrome. , : .
[12] J.Clin. Med. . .. , 9 : .
[13] Lunardelli M.M.,Becker M.W.,Ortiz G.X.,Blatt C.R. .2022 .. , : .
[14] .2022 .Drug-induced liver injury causality assessment data from a crosssectional study in Brazil: A call for the use of updated RUCAM in hospital pharmacy. Braz. J. Hosp. Pharm. Health Serv., 132 : .
[15] Bughdadi F.A.,Saleh S.Y. .2014 .A comparative studyon the effects of enzymes feed additive "Kemzymeand antibiotic growth promoter Salinomycin on Haemostatic mechanism of rabbit bucks. J. Agric. Sci., 6 : 161-166.
[16] Subramani B. and P.,Sathiyarajeswaran B. and P. .2022 .Current update on herbal sources of antithrombotic activity-A comprehensive review. Egypt. J. Intemn. Med, 34 : .
[17] Chojnacka-Purpurowicz J,Owczarczyk-Saczonek A,Nedoszytko B. .2024 .The role of gamma delta Tlymphocytes in physiological and pathological condition-focus on psoriasis, atopic dermatitis, autoimmune disorders, cancer and lymphomas. Int. J. Mol. Sci, 25 : .
[18] . .. , : .
[19] Zaki AA .2016 .. HH. Ahmed and KA. Attia, : .
[20] Environ . .. , 2 : 580-589.
[21] Hirsh J.,Eikelboom J.W.,Chan N.C. .2019 .Fifty years of research on antithrombotic therapy: Achievements and disappointments. Eur. J. Intern. Med, 70 : 1-7.
[22] Chuttong B,Lim K.,Praphawilai P.,Danmek K.,Maitip J. .2023 .Exploring the functional properties of propolis, geopropolis, and cerumen, with a special emphasis on their antimicrobial effects. Foods, 12 : .
[23] . .. , : .
[24] Campos J.F,Bonamigo T.,MB V. .2023 .Antimicrobial activity of propolis from the Brazilian stingless bees Meljpona quadrifasciata anthidioides and Scaptotrigona depilis (Hymenoptera, Apidae. Microorganisms, 11 : .
[25] . .. , : .
[26] Mitek M.,Ciszkowicz E.,Tomczyk M.,Sidor E.,Zaguta G. .2022 .The study of chemical profile and antioxidant properties of poplar-type polish propolis considering local flora diversityin relation to antibacterial and anticancer activitiesin human breast cancer cells. Molecules, 27 : .
[27] Arathi E.,Bernklau E. .2021 .Context-dependent effect of dietary phytochemicals on honey bees exposed to a pesticide, thiamethoxam. J. Insect Sci, 21 : .
[28] . .. , : .
[29] Hossain R,Ray P. .2022 .An update on its chemistry and pharmacological applications. Chin. Med, 17 : .
[30] Salatino A,Salatino M.LF.,Negri G. .2021 .How diverse is the chemistry and plant origin of Brazilian propolis?. Apidologie, 52 : 1075-1097.
[31] Mendez-Pfeiffer P,Carreiio A.L.,Montafo-Leyva B. .2020 .Seasonality modulates the cellular antioxidant activity and antiproliferative effect of Sonoran desert propolis. Antioxidants, 9 : .
[32] . .. , : .
[33] de Abreu Barreto G.,Cerqueira J.C.,Gama J.C. .2022 .Evaluation of the potential of Brazilian red propolis extracts: An analysis of the chemical composition and biological properties. Appl. Sci., 12 : .
[34] Silva H.,Francisco R.,Saraiva A.,Carrascosa C.,Raposo A. .2021 .The cardiovascular therapeutic potential of propolis-A comprehensive review. Biology, 10 : .
[35] . .. , : .
[36] Lv L,Cui Z.,Ma X.,Liu L,Yang L .2021 .Recent progresses in the pharmacological activities of caffeic acid phenethyl ester. Naunyn-Schmiedeberg s Arch. Pharmacol, 394 : 1327-1339.
[37] Fuentes S.,Wehinger A.,Trostchansky A. .2021 .. , : .
[38] . .Regulation of key antiplatelet pathways by bioactive compounds with minimal bleeding risk. Int. J. Mol. Sci,, 22 : .
[39] Lee S.H.,Lee B.l.,Gil K.A.,Lee K.A. .2024 ./n vitro biological activities of hesperidin-related compounds with different solubility. , 13 : .
[40] . .. , : .
[41] Youssef AMM,Al-Saraireh Y.M. .2023 .. , : .
[42] . .Phytochemistry and anticancer effects of mangrove (Rhizophora mucronata Lam.) leaves and stems extract against different cancer cell lines. Pharmaceuticals, 16 : .
[43] . .. , : .
[44] M.A. Camilo L.G.,Marques L.G.,C.M. de Oliveira SA .2020 .Increased warfarin anticoagulant activity and its potential interaction with aqueous extract of goji berry (Lycium barbarum L)) in Wistar rats. Res. Soc. Dev., 9 : 11070.
[45] Rodriguez L,Wood I.,Palomo S.,WehingerandE. Fuentes S. .2022 .Acomprehensive literature review on cardioprotective effects of bioactive compounds present in fruits of Aristotelia chilensis Stuntz (Maqui).. , : .
[46] Molecules . .. , 27 : .
[47] Fouad AM,Ruan D.,El-Senousey W.,Chen S.,Jiang C.,Zheng C. .2019 .Harmful effects and control strategies of aflatoxin B, produced by Aspergillus flavus and Aspergillus parasiticus strains on poultry: Review. , 11 : .
[48] . .. , : .
[49] Meradi S.,Messai A.,Aouachria M.,Trigonella L.,Pimpinella L. .2022 .andtheir combinations on growth performance, carcass trait, and hematobiochemical parameters in broiler chicken. Vet, 15 : 1821-1826.
[50] Lai Y.,He J.,Gao X.,Peng D. .2023 .. , : .
[51] . .Involvement of plasminogen activator inhibitor-1 in p300/p53-mediated age-related atrial fibrosis. PeerJ, 11 : .
[52] . .. , 16545 : .
[53] Ismail A.A,BT. Shaker K.,Bajou K. .2022 .The plasminogen-activator plasmin system in physiological and pathophysiological angiogenesis. Int. J. Mol. Sci., 23 : .
[54] . .. , : .
[55] Attia KA,Anim KA .1998 .Some haemostatic parameters of buffalo-calves kepton natural milk with reference to the role of vitamin-K. Egypt. , 35 : 81-90.
[56] Attia KA.,El-Badawi KA. .2015 .Effects of short or long-term exposure of dithiopyr on certaine blood, growth and tissue biochemical parameters in catfish (Clarias garipinus). Int. ). Appl. Sci. Biotechnol, 3 : 314-321.
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