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Synthesis, characterization and antibacterial activities of two new Schiff bases devired from (E)-2-(((2-aminoethyl) imino) methyl) phenol (E)-2-(4-aminobut-1-enyl)-5-methylbenzamine
Author(s)
Sheheryar Department of Biochemistry and Molecular Biology, Federal University of Ceara Brazil,,
Saira Farman Department of Biochemistry Abdul Wali Khan University Mardan,,Pakistan
Faheem Jan Ministry of National Health Services, Regulation and Coordination, National TB Control Program,Islamabad,Pakistan
Nicole Ferreira dos Santos Federal University of Ceara Center of Agrarian Sciences.,,Brazil
Asif Khan Laboratory of Phytochemistry, Department of Botany, University of São Paulo Brazil,,
Mohib Ullah Shah Faculty of Sciences, Bahauddin Zakariya University,,Pakistan
Alia Gul Department of Botany, Hazara University Mansehra,,Pakistan
Abstract
In the present studies two new Schiff bases ligands (E)-2-(4-aminobut-1-enyl) phenol and (E)-2-(4-aminobut-1-enyl)-5methylaniline were synthesized. The compounds were properly characterized through FT-IR and elemental analysis and its antibacterial activities were checked against Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Salmonella typhimurium and Staphylococcus aureus. The Schiff base ligands were screened o for their antibacterial inhibiting potentials through Disc-diffusion method, in vitro. The results indicated that as compared to control i.e. Ciprofloxacin and Erythromycin the Schiff base have significant biological activity against E. coli, while no effective inhibition was noted for other tested bacterial strains. This research highlighted Schiff bases an effective drug against the E. coli.
Publication Details
Page(s) 925-929
DOI DOI not available
Published Journal: Bioscience Research, Volume: 19, Issue: 2, Year: 2022
Keywords
antibacterial FTIR chemical synthesis Schiff base
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