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Y-chromosomal deletions - A risk factor for male infertility.
Author(s)
Saima Siddiqi Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan
Anjum Siddiq Islamabad Clinic Serving Infertile Couples (ICSI) Center, Pak-Saudi Tower, Islamabad, Pakistan
Kamran Majeed Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan
Atika Mansoor Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan
Raheel Qamer COMSATS Institute of Information Technology, Islamabad, Pakistan
Kehkashan Mazhar Salma and Kafeel Medical Center, F7/4, Islamabad, Pakistan
Naseem Ashraf Islamabad Clinic Serving Infertile Couples (ICSI) Center, Pak-Saudi Tower, Islamabad, Pakistan
Salma Kafeel Salma and Kafeel Medical Center, F7/4, Islamabad, Pakistan
Azra Khanum Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi-4600, Pakistan
Khalid Mehmood Khan Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi-4600, Pakistan
Abstract
In this study, contribution of micro-deletion towards male infertility among Pakistani male individuals has been described. Our analyses involved evaluation of seven genetic markers spanning the AZFa, b and c region among infertile males and observed micro-deletions were compared with the control healthy fertile counterparts. Data revealed AZFa deletion in 2% infertile azoospermic and oligospermic males, while the AZFb and AZFc deletions were found in 3.8 and 5.8% infertile males, respectively. These deletions were found solely in non-obstructive azoospermic patients, which consisted of 17.6% of the total non-obstructive infertile males. Our data clearly demonstrate association of Y-chromosomal micro-deletions with male infertility.
Publication Details
Page(s) 110-112
DOI DOI not available
Published Journal: International Journal of Agriculture and Biology, Volume: 11, Issue: 1, Year: 2009
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