Abstract:
In biotic and abiotic components of the ecosystem, pesticides are known as the most potent environmental contaminants. A dithiocarbamate fungicide, Propineb (Pro) is widely used to control the fungal infections on crops. The present study was conducted to investigate the abnormal sperm morphology due to the effects of short term exposure of Propineb (Pro) in 75 male mice (Mus musculus) germ cells. Mice were injected intraperitoneally with doses of 0.625 ug mL-1 , 1.250 ug mL-1 and 2.500 ug mL-1 of Pro over a period of 24, 48 and 72 H treatment. A positive control of Mitomycin C (MMC) and a negative control of distilled water were also used. The frequency of abnormal sperm induced by Pro observed at the highest concentrations for 24, 48 and 72 H was “Hookless Head” as compared with the negative controls. Results suggest that due to the observed increase in the frequency of sperm abnormalities, Propineb may has been germ cell mutagen.
Page(s):
369-373
DOI:
DOI not available
Published:
Journal: Biologia, Volume: 62, Issue: 2, Year: 2016