Abstract:
Forty patients were included in the study (20 patients each for Spiramycine and Ampicillin-Cloxacillin) (Ampn-cloxn) of which 26 were males and 14 were females mean age was 21 years (16-58 years). The indications in which drugs were assessed include acute tonsillitis 55%, acute Pharyngitis 30% and acute Sinsusitis 15%. The dosage was one Tab. 1.5 M.I.U. (500 mg.) T.I.D. for 3 days in Spiramycine group and 500 mg. T.I.D. for 5 days in Ampn-cloxn group. 16.20 (80%) were cured and 4/20 (20%) showed improvement in spiramycin group whereas in Apn-cloxn group 8/20 (40%) were evaluated as cured and 8/20 (40%) showed improvement while 4/20 (20%) did not respond. Diarrhoea was reported in 20% of patients in Ampn-cloxn group and 10% in Spiramycine group. Other side effects were G.I. intolerance 10%, abdominal cramps and skin rashes 5% in Ampn-cloxn group. On these basis Spiramycine may be considered more effective and tolerable as compared to Amp-cloxn in upper respirary infections.
Page(s):
44-46
DOI:
DOI not available
Published:
Journal: Pakistan Journal of Otolaryngology,Head and Neck Surgery, Volume: 8, Issue: 1, Year: 1992