A comparative study between t-spot and tuberculin skin tests for the diagnosis of tuberculosis | [Rawal Medical Journal • 2020]

Author(s):

1. Ishtiaq Ishtiaq: Faculty of Allied Health Sciences, The University of Lahore,Lahore,Pakistan

2. Muhmmad Javaid Asad: Faculty of Allied Health Sciences, The University of Lahore,Lahore,Pakistan

3. Jamila: Islamabad diagnostic Center, Wah Medical College,Pakistan

4. Muhammad Umer Khan: Islamabad diagnostic Center, Wah Medical College,Pakistan

5. Tahira Tehseen: The University of Lahore,Lahore,Pakistan

6. Rizwan Ahmed Kiani: Islamabad diagnostic Center, Wah Medical College,Pakistan

Abstract:

Objective: To compare tuberculin skin test (TST) with T-Spot for diagnosis of active tuberculosis (TB) as well as latent tuberculosis infection (LTBI). Methodology: This study was conducted at Department of Immunology, Islamabad diagnostic Center, Islamabad from January to December 2018. Blood Samples of 126 individuals for T SPOT and same patients were inoculated with PPD (Mantoux test). Results: Among 126 participants, 64 (50.8%) were male and 62 (49.2%) were female. T-Spot. was positive in 52 (41.0%) while PPD was positive in 13 (10%). Furthermore, 25 (19.84%) T-Spot. TB test was positive for male while tuberculin skin test was positive in 6 (4.7%) male. T-Spot. was positive in 27 (21.4%) female while PPD was positive in 7 (5.5%). Additionally, one (0.79%) patient each of males and females was also found to be intermediate positive for PPD, which was clearly positive for T-Spot. TB test.Conclusion: T-Spot. was much more sensitive and specific in all age groups and different clinical conditions including immune-compromised individuals. Skin test has limitation especially for older age groups but in T-Spot. is unaffected by age and provides excellent agreement.

Page(s): 510-512

DOI: DOI not available

Published: Journal: Rawal Medical Journal, Volume: 45, Issue: 3, Year: 2020

Keywords:

PPD , Tuberclosis , IGRA , T Spot , Tuberclin skin test

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