Abstract:
People deal with dominant and challenging health problems caused by peripheral nerve injuries (PNIs). These are one of the most typical forms of injuries. From traumatic causes, most peripheral nerve injuries occur, and they affect the upper limbs. The scientific community, from plastic surgeons to neurologists to neuroscientists, are the experts in the field of PNI. Full functional recovery is still rare, despite attempts. In many neurological and other diseases, some confirmation of effectiveness and diverse effects have been shown by numerous medicinal plants. In a mouse model for the maintenance of peripheral nerve injury, the role of chitosan-coated nanoparticles of Calotropis procera (Calotropis procera/Cht-NPs) was determined. It is the goal of this study.In living animals, to investigate the process of peripheral nerve injury, experimental models have been created. Mice were divided evenly into two groups after the phase of acclimatization. In the treatment group (group 2) gavage with C. procera/Cht-NPs (2.5 mg/kg/day) on the other hand, normal chow was given to the control group. The right sciatic nerve of animals was mechanically crushed. For evaluation of sensorimotor function recovery, behavioral analyses (hot plate, grip strength, SFI, and pinprick test) were performed. For the evaluation of oxidative stress, blood was drawn. With a statistically significant difference (p<.05), C. procera/Cht-NPs support motor and sensory function retrieval after the PNI. It is revealed by our research. In conclusion, a function restoration-enhancing effect is shown by the C. procera/Cht-NPs. More thorough research on their use as therapeutic agents is highly suggested.
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DOI:
DOI not available
Published:
Journal: Abstract Book on 9th Annual Neuroscience Conference (ANC-23) August 12-13, 2023 , Volume: 0, Issue: 0, Year: 2023