A Comprehensive Review on Implementation of Quality by Design in Varied Pharmaceutical Formulations | [Global Pharmaceutical Sciences Review • 2024]

Author(s):

1. Aqsa Qaisar: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

2. Maryam Sikandar: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

3. Rehan Rustam: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

4. Afifa Uppal: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

5. Muhammad Adnan: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

6. Zahid Ali: Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

Abstract:

This review article investigates how Quality by Design (QbD) ideas are used in different pharmaceutical development processes, such as the creation of analytical methods, formulation optimization, and nanoparticle production. In order to improve product quality, reliability, and regulatory compliance, it covers a variety of studies that use QbD approaches. Critical quality attributes and process variables are discovered and optimized to meet desired product characteristics through systematic methodologies such as central composite design, factorial design, and response surface analysis. The experiments demonstrate the adaptability and effectiveness of the QbD strategy in pharmaceutical development by examining a range of drug delivery systems, including lipid nanoparticles and fast-dissolving tablets. The significance of QbD is emphasized in the article as a means of guaranteeing uniform product quality, fulfilling regulatory obligations, and enhancing patient outcomes.

Page(s): 1-9

DOI: 10.31703/gpsr.2024(IX-I)

Published: Journal: Global Pharmaceutical Sciences Review, Volume: 9, Issue: 1, Year: 2024

Keywords:

formulation development , pharmaceuticals , quality by design , Design Space

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